The volume presents essays on the philosophical explanation of the relationship between body and soul in antiquity from the Presocratics to Galen. The title of the volume alludes to a phrase found in Plato, Aristotle and Plotinus, referring to aspects of living behaviour involving both body and soul, and is a commonplace in ancient philosophy, dealt with in very different ways by different authors.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

"Neuroscience and Philosophy" begins with an excerpt from "Philosophical Foundations of Neuroscience," in which Maxwell Bennett and Peter Hacker question the ...

Elementary education students enrolled in both science methods and social studies methods coursework implemented standards-based STS lessons during their clinical experience. Data were collected from preservice teachers, elementary/middle school students, and cooperating in-service teachers. Findings from each school group include (a) preservice teachers' content knowledge in science and social studies hindered their development of meaningful STS curriculum, (b) the STS curriculum development and implementation experience increased preservice teachers' anxieties, (c) interviews with elementary students after the STS learning suggest that they (...) did achieve some understanding of science and social studies, and (d) cooperating in-service teachers' conceptualization of curriculum differed from the science and social studies professors' understanding. (shrink)

Among the works of Aelius Aristides is preserved an address to an unnamed ‘king’. The prevailing view in this century has been that it is addressed to a third-century emperor, and was attributed to Aristides in error. In an article published in 1972 , 134–52), I argued that the speech was genuine, and was delivered by Aristides in 144 before Antoninus Pius. In a recent article in this journal , 172–97), Stephen A. Stertz has undertaken to rebut this view, (...) and advances a novel one: the speech is a school exercise written in the third or perhaps the fourth century, and does not refer to any particular ‘king’, not even necessarily a Roman emperor. Rather than attempt to answer all of Stertz's arguments, I have selected as samples one each from several diverse fields. Manuscript tradition. In his first paragraph, Stertz suggests that the manuscript tradition of the Eis basilea itself impugns its authenticity. ‘The oration is entitled єς βασιλέα in three manuscripts and єς τόν ατοκρτορα in another. It has been pointed out that in the former group of manuscripts the title is not preceded by the words ριστεδου λόγος, thus casting doubt on Aristidean authorship' . The accompanying footnote refers to Keil's apparatus ad loc, and the reader might infer that this argument is borrowed from Aristides’ foremost editor. What Keil said was: ‘Titulus ες βασιλα STC : єς τòν ατοκρτορα U et in indice D m recentiss.’. (shrink)

Among the works of Aelius Aristides is preserved an address to an unnamed ‘king’. The prevailing view in this century has been that it is addressed to a third-century emperor, and was attributed to Aristides in error. In an article published in 1972, 134–52), I argued that the speech was genuine, and was delivered by Aristides in 144 before Antoninus Pius. In a recent article in this journal, 172–97), Stephen A. Stertz has undertaken to rebut this view, and advances (...) a novel one: the speech is a school exercise written in the third or perhaps the fourth century, and does not refer to any particular ‘king’, not even necessarily a Roman emperor. Rather than attempt to answer all of Stertz's arguments, I have selected as samples one each from several diverse fields. Manuscript tradition. In his first paragraph, Stertz suggests that the manuscript tradition of the Eis basilea itself impugns its authenticity. ‘The oration is entitled єς βασιλέα in three manuscripts and єς τόν ατοκρτορα in another. It has been pointed out that in the former group of manuscripts the title is not preceded by the words ριστεδου λόγος, thus casting doubt on Aristidean authorship'. The accompanying footnote refers to Keil's apparatus ad loc, and the reader might infer that this argument is borrowed from Aristides’ foremost editor. What Keil said was: ‘Titulus ες βασιλα STC : єς τòν ατοκρτορα U et in indice D m recentiss.’. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

The intent of ethics is to establish a set of standards that will provide a framework to modify, regulate, and possibly enhance moral behaviour. Eleven focus groups were conducted with physicians from six culturally distinct countries to explore their perception of formalized, written ethical guidelines (i.e., codes of ethics, credos, value and mission statements) that attempt to direct their ethical practice. Six themes emerged from the data: lack of awareness, no impact, marginal impact, other codes or value statements supersede, personal (...) codes or values dictate, and ethical guidelines are useful. Overall, codes were valued only when they were congruent with existing personal morality. The findings suggest the need to re-evaluate the purpose, content, and delivery of codes for them to improve their function in promoting ethical conduct. (shrink)

In this paper we describe the objectives of teaching medical ethics to undergraduates and the teaching methods used. We describe a workshop used in the University of Liverpool Department of Psychiatry, designed to enhance ethical sensitivity in psychiatry. The workshop reviews significant historical and current errors in the ethical practice of psychiatry and doctors' defence mechanisms against accepting responsibility for deficiencies in ethical practice. The workshop explores the student doctors' own group ethos in response to ethical dilemmas, and demonstrates how (...) the individual contributes to and is responsible for the group ethos through participation and also through nonparticipation. The student feedback about the workshop is reviewed. The Toronto Ethical Sensitivity Instrument was used to assess whether or not the workshop altered sensitivity. Compared to a control group the attenders' sensitivity was significantly increased (on Student's t-test p equals or is less than 0.002). (shrink)

In this paper we try to answer the question whether diffusion is a possible mechanism to explain mesoderm induction in Amphibians. First the embryological data are discussed and a hypothesis for mesoderm formation is set forth. The blastula being essentially a hollow sphere, we assume that the induction mechanism in an embryo at the blastula stage can be simulated by diffusion-reaction processes on spherical surfaces. A model is constructed for the simple case when the source is held constant with respect (...) to time, the decay proportional to the concentration and the diffusion coefficient a constant, From simulation we find a (best) value for the decay constant to be 6 × 10–5/sec and for the diffusion constant to be 0.24 × 10– 6 cm2/sec. The relation between the parameters is derived from an analytic solution for the diffusion process on a spherical surface with a continuously producing point source and the concentration proportional to the decay. The form and regulative properties of the steady concentration gradient are discussed. (shrink)

A scholarly edition of a work by Adam Smith. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

We present an experimental test of the validity of the Pauli Exclusion Principle for electrons based on the concept put forward a few years ago by Ramberg and Snow. In this experiment we perform a very accurate search of X-rays from the Pauli-forbidden atomic transitions of electrons in the already filled 1S shells of copper atoms. Although the experiment has a simple structure, it poses deep conceptual and interpretational problems. Here we describe the experimental method and recent experimental results, which (...) we interpret as an upper limit for the probability to violate the Pauli Exclusion Principle. We present also future plans to upgrade the experimental apparatus using Silicon Drift Detectors. (shrink)

In this paper we describe an experimental test of the validity of the Pauli Exclusion Principle (for electrons) which is based on a straightforward idea put forward a few years ago by Ramberg and Snow (Phys. Lett. B 238:438, 1990). We perform a very accurate search of X-rays from the Pauli-forbidden atomic transitions of electrons in the already filled 1S shells of copper atoms. Although the experiment has a very simple structure, it poses deep conceptual and interpretational problems. Here we (...) describe the experimental method and recent experimental results, which we interpret in the framework of quon theory. We also present future plans to upgrade the experimental apparatus using Silicon Drift Detectors. (shrink)

We present the idea of searching for X-rays as a signature of the mechanism inducing the spontaneous collapse of the wave function. Such a signal is predicted by the continuous spontaneous localization theories, which are solving the “measurement problem” by modifying the Schrödinger equation. We will show some encouraging preliminary results and discuss future plans and strategy.

Some philosophers understand natural kinds to be the categories which are constraints on enquiry. In order to elaborate the metaphysics appropriate to such an account, I consider the complicated history of scurvy, citrus, and vitamin C. It may be tempting to understand these categories in a shallow way (as mere property clusters) or in a deep way (as fundamental properties). Neither approach is adequate, and the case instead calls for middle-range ontology: starting from categories which we identify in the world (...) and elaborating their structure, but not pretending to jump ahead to a complete story about fundamental being. (shrink)